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Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action

The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain diseases, such as tauopathies, they remarkably differ in t...

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Detalles Bibliográficos
Autores principales: Paskus, Jeremiah D., Tian, Chen, Fingleton, Erin, Shen, Christine, Chen, Xiaobing, Li, Yan, Myers, Samuel A., Badger, John D., Bemben, Michael A., Herring, Bruce E., Roche, Katherine W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012321/
https://www.ncbi.nlm.nih.gov/pubmed/31801062
http://dx.doi.org/10.1016/j.celrep.2019.10.115