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Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching

Vascular smooth muscle cells (VSMCs) play a central role in the progression of atherosclerosis, where they switch from a contractile to a synthetic phenotype. Because of their role as risk factors for atherosclerosis, we sought here to systematically study the impact of matrix stiffness and (hemodyn...

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Detalles Bibliográficos
Autores principales: Swiatlowska, Pamela, Sit, Brian, Feng, Zhen, Marhuenda, Emilie, Xanthis, Ioannis, Zingaro, Simona, Ward, Matthew, Zhou, Xinmiao, Xiao, Qingzhong, Shanahan, Cathy, Jones, Gareth E., Yu, Cheng-han, Iskratsch, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012473/
https://www.ncbi.nlm.nih.gov/pubmed/35427166
http://dx.doi.org/10.1126/sciadv.abm3471