Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is a key player in cardiomyocyte calcium handling and also a classic target in the gene therapy for heart failure. SERCA2 expression dramatically increases during cardiomyocyte maturation in the postnatal phase of heart development, which...

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Detalles Bibliográficos
Autores principales: Lin, Junsen, Chen, Zhan, Yang, Luzi, Liu, Lei, Yue, Peng, Sun, Yueshen, Zhao, Mingming, Guo, Xiaoling, Hu, Xiaomin, Zhang, Yan, Zhang, Hong, Li, Yifei, Guo, Yuxuan, Dong, Erdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012521/
https://www.ncbi.nlm.nih.gov/pubmed/35433671
http://dx.doi.org/10.3389/fcell.2022.864516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012521/
https://www.ncbi.nlm.nih.gov/pubmed/35433671
http://dx.doi.org/10.3389/fcell.2022.864516

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