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CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
miRNAs form a class of noncoding RNAs, involved in post-transcriptional regulation of gene expression, broadly studied for their involvement in physiological and pathological context. Inhibition of mature miRNA transcripts, commonly used in miRNA loss-of-function experiments, may not be specific in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012752/ https://www.ncbi.nlm.nih.gov/pubmed/35428787 http://dx.doi.org/10.1038/s41598-022-10336-3 |