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Serotonergic system in vivo with [(11)C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients

GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brai...

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Detalles Bibliográficos
Autores principales: Timmers, Elze R., Peretti, Débora E., Smit, Marenka, de Jong, Bauke M., Dierckx, Rudi A. J. O., Kuiper, Anouk, de Koning, Tom J., Vállez García, David, Tijssen, Marina A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012759/
https://www.ncbi.nlm.nih.gov/pubmed/35428769
http://dx.doi.org/10.1038/s41598-022-10067-5