Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism

Patients with late-stage and human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) continue to have a very poor prognosis. The development of more effective novel therapies that improve overall survival and overcome drug resistance is an urgent priority. Here we report th...

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Detalles Bibliográficos
Autores principales: Jones, Trace M., Espitia, Claudia M., Ooi, Aikseng, Bauman, Julie E., Carew, Jennifer S., Nawrocki, Steffan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012827/
https://www.ncbi.nlm.nih.gov/pubmed/35428778
http://dx.doi.org/10.1038/s41419-022-04798-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012827/
https://www.ncbi.nlm.nih.gov/pubmed/35428778
http://dx.doi.org/10.1038/s41419-022-04798-6

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