Cargando…

The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer

Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis to fuel rapid proliferation even in the presence of oxygen, and elevated glycolysis is coupled to lactate fermentation in the cancer microenvironment. Although lactate has been recognized as a metabolic waste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishihara, Shota, Hata, Kenji, Hirose, Katsutoshi, Okui, Tatsuo, Toyosawa, Satoru, Uzawa, Narikazu, Nishimura, Riko, Yoneda, Toshiyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012857/ https://www.ncbi.nlm.nih.gov/pubmed/35428832 http://dx.doi.org/10.1038/s41598-022-10143-w

Ejemplares similares

Lactate secreted via MCT4 from bone-colonizing breast cancer excites sensory neurons via GPR81
por: Okui, Tatsuo, et al.
Publicado: (2023)

Sensory nerves: A driver of the vicious cycle in bone metastasis?
por: Yoneda, Toshiyuki, et al.
Publicado: (2021)

Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
por: Laroche, Samuel, et al.
Publicado: (2021)

3-OBA Is Not an Antagonist of GPR81
por: Mohammad Nezhady, Mohammad Ali, et al.
Publicado: (2022)

The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons
por: OKUI, TATSUO, et al.
Publicado: (2023)

The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro
por: Boitsova, Elizaveta B., et al.
Publicado: (2018)

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
por: Khatib-Massalha, Eman, et al.
Publicado: (2020)

Dual Roles of Lactate in EGFR-TKI-Resistant Lung Cancer by Targeting GPR81 and MCT1
por: Ma, Ruishuang, et al.
Publicado: (2022)

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
por: Errea, Agustina, et al.
Publicado: (2016)

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
por: Ono, Koichiro, et al.
Publicado: (2021)

The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress
por: Longhitano, Lucia, et al.
Publicado: (2022)

LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS
por: Fan, Min, et al.
Publicado: (2022)

Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway
por: Yang, Libang, et al.
Publicado: (2023)

Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin
por: Chen, Shaomeng, et al.
Publicado: (2021)

Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
por: Lundø, Kathrine, et al.
Publicado: (2023)

Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation
por: Jones, Natalie K., et al.
Publicado: (2020)

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling
por: Yang, Kun, et al.
Publicado: (2020)

PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)
por: Hori, Yumiko, et al.
Publicado: (2022)

Correction: PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibro-adipose vascular anomaly (FAVA)
por: Hori, Yumiko, et al.
Publicado: (2022)

Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis
por: Luo, Man, et al.
Publicado: (2022)

GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancer
por: li, Xiaofeng, et al.
Publicado: (2023)

Lactate is always the end product of glycolysis
por: Rogatzki, Matthew J., et al.
Publicado: (2015)

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants
por: Vohra, Rupali, et al.
Publicado: (2022)

Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature
por: Toyodome, Soichiro, et al.
Publicado: (2023)

Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription
por: Amano, Katsuhiko, et al.
Publicado: (2011)

Glycolysis and the significance of lactate in traumatic brain injury
por: Carpenter, Keri L. H., et al.
Publicado: (2015)

Transcriptional Network Controlling Endochondral Ossification
por: Hata, Kenji, et al.
Publicado: (2017)

Effects of GPR81 silencing combined with cisplatin stimulation on biological function in hypopharyngeal squamous cell carcinoma
por: Jia, Qiaojing, et al.
Publicado: (2020)

Comment on Chen et al. Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin. Biomolecules 2021, 11, 1373
por: Stransky, Nicolai, et al.
Publicado: (2022)

Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes
por: Lund, Jenny, et al.
Publicado: (2019)

Activation and Function of NLRP3 Inflammasome in Bone and Joint-Related Diseases
por: Murakami, Tomohiko, et al.
Publicado: (2022)

Primary ameloblastic carcinoma of the maxilla: A case report and literature review
por: UZAWA, NARIKAZU, et al.
Publicado: (2015)

Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
por: Lu, Xia, et al.
Publicado: (2021)

Multiple orthokeratinized odontogenic cysts: clinical, pathological, and genetic characteristics
por: Ono, Sawako, et al.
Publicado: (2022)

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
por: Jiang, Bo
Publicado: (2017)

Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism
por: Horvat, Anemari, et al.
Publicado: (2021)

Lactate is a bridge linking glycolysis and autophagy through lactylation
por: Sun, Weixia, et al.
Publicado: (2023)

Metabolic Reprogramming toward Aerobic Glycolysis and the Gut Microbiota Involved in the Brain Amyloid Pathology
por: Murai, Toshiyuki, et al.
Publicado: (2023)

The role of GRP81 lactate receptor in synaptic transmission regulation: does it enhance endocytosis?
por: Fedorovich, Sergei V., et al.
Publicado: (2022)

Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway
por: Hori, Yumiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_keb8rf9bn9131p9ofd2raguq4a