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srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability

The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasation of plasma proteins and leukocytes. Here we sho...

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Detalles Bibliográficos
Autores principales: Lopez Rioja, Alba, Faulkner, Ashton, Mellor, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012936/
https://www.ncbi.nlm.nih.gov/pubmed/35441126
http://dx.doi.org/10.1530/VB-21-0012