BreakAlign: a Perl program to align chimaeric (split) genomic NGS reads and allow visual confirmation of novel retroviral integrations

BACKGROUND: Retroviruses replicate by integrating a DNA copy into a host chromosome. Detecting novel retroviral integrations (ones not in the reference genome sequence of the host) from genomic NGS data is bioinformatically challenging and frequently produces many false positives. One common method...

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Detalles Bibliográficos
Autores principales: Marchi, Emanuele, Jones, Mathew, Klenerman, Paul, Frater, John, Magiorkinis, Gkikas, Belshaw, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013057/
https://www.ncbi.nlm.nih.gov/pubmed/35428171
http://dx.doi.org/10.1186/s12859-022-04621-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013057/
https://www.ncbi.nlm.nih.gov/pubmed/35428171
http://dx.doi.org/10.1186/s12859-022-04621-1

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