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CRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detection
BACKGROUND AND AIMS: The formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver is the main cause of persistent hepatitis B virus (HBV) infection. Here, we established highly sensitive and specific methods to detect cccDNA based on CRISPR-Cas13a technology. METHODS...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013339/ https://www.ncbi.nlm.nih.gov/pubmed/35298777 http://dx.doi.org/10.1007/s12072-022-10311-0 |