CRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detection

BACKGROUND AND AIMS: The formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver is the main cause of persistent hepatitis B virus (HBV) infection. Here, we established highly sensitive and specific methods to detect cccDNA based on CRISPR-Cas13a technology. METHODS...

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Detalles Bibliográficos
Autores principales: Zhang, Xiangying, Tian, Yuan, Xu, Ling, Fan, Zihao, Cao, Yaling, Ma, Yingmin, Li, Hao, Ren, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013339/
https://www.ncbi.nlm.nih.gov/pubmed/35298777
http://dx.doi.org/10.1007/s12072-022-10311-0

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