Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome(™) cytochromes P450 (CYP)-specific kinetic data as model input

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF...

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Detalles Bibliográficos
Autores principales: Zhao, Shensheng, Wesseling, Sebastiaan, Rietjens, Ivonne. M. C. M., Strikwold, Marije
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013686/
https://www.ncbi.nlm.nih.gov/pubmed/35294598
http://dx.doi.org/10.1007/s00204-022-03251-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013686/
https://www.ncbi.nlm.nih.gov/pubmed/35294598
http://dx.doi.org/10.1007/s00204-022-03251-z

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