Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances

The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food additives and novel food ingredients. Micronucleus assays typically utilise homogenous in vitro cell lines which poorly recapitulate the physiology, b...

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Detalles Bibliográficos
Autores principales: Lim, Hui Kheng, Hughes, Christopher Owen, Lim, Michelle Jing Sin, Li, Jia’En Jasmine, Rakshit, Moumita, Yeo, Calvin, Chng, Kern Rei, Li, Angela, Chan, Joanne Sheot Harn, Ng, Kee Woei, Leavesley, David Ian, Smith, Benjamin Paul Chapman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013689/
https://www.ncbi.nlm.nih.gov/pubmed/35226136
http://dx.doi.org/10.1007/s00204-022-03228-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013689/
https://www.ncbi.nlm.nih.gov/pubmed/35226136
http://dx.doi.org/10.1007/s00204-022-03228-y

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