Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling

Alzheimer’s disease (AD) is characterized by the deposition of aggregated species of amyloid beta (Aβ) in the brain, which leads to progressive cognitive deficits and dementia. Aβ is generated by the successive cleavage of the amyloid precursor protein (APP), first by β-site APP cleaving enzyme 1 (B...

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Detalles Bibliográficos
Autores principales: Antonino, Magdalena, Marmo, Paula, Freites, Carlos Leandro, Quassollo, Gonzalo Emiliano, Sánchez, Maria Florencia, Lorenzo, Alfredo, Bignante, Elena Anahi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013780/
https://www.ncbi.nlm.nih.gov/pubmed/35445022
http://dx.doi.org/10.3389/fcell.2022.852738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013780/
https://www.ncbi.nlm.nih.gov/pubmed/35445022
http://dx.doi.org/10.3389/fcell.2022.852738

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