Evidence for Bell-Shaped Dose-Response Emetic Effects of Temsirolimus and Analogs: The Broad-Spectrum Antiemetic Efficacy of a Large Dose of Temsirolimus Against Diverse Emetogens in the Least Shrew (Cryptotis parva)

Temsirolimus is a prodrug form of sirolimus (rapamycin). With its analogs (everolimus, ridaforolimus, and rapamycin), it forms a group of anticancer agents that block the activity of one of the two mammalian targets of rapamycin (mTOR) complexes, mTORC1. We investigated the emetic potential of varyi...

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Detalles Bibliográficos
Autores principales: Belkacemi, Louiza, Sun, Yina, Darmani, Nissar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014009/
https://www.ncbi.nlm.nih.gov/pubmed/35444553
http://dx.doi.org/10.3389/fphar.2022.848673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014009/
https://www.ncbi.nlm.nih.gov/pubmed/35444553
http://dx.doi.org/10.3389/fphar.2022.848673

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