A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the individual FAS-II components during the progres...

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Detalles Bibliográficos
Autores principales: Li, Mengmiao, Huang, Qian, Zhang, Weidi, Cao, Yinghua, Wang, Zhanxin, Zhao, Zhenwen, Zhang, Xiaotian, Zhang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014085/
https://www.ncbi.nlm.nih.gov/pubmed/35444621
http://dx.doi.org/10.3389/fmicb.2022.846722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014085/
https://www.ncbi.nlm.nih.gov/pubmed/35444621
http://dx.doi.org/10.3389/fmicb.2022.846722

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