Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa

PURPOSE: Bintrafusp alfa is a bifunctional agent consisting of an anti-human PD-L1 antibody linked to two TGFβRII. It is designed to act both as a checkpoint inhibitor and to ‘trap’ TGFβ in the tumor microenvironment. Phase I and II clinical studies demonstrated clinical activity in patients with a...

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Detalles Bibliográficos
Autores principales: Tsai, Yo-Ting, Strauss, Julius, Toney, Nicole J, Jochems, Caroline, Venzon, David J, Gulley, James L, Schlom, Jeffrey, Donahue, Renee N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014099/
https://www.ncbi.nlm.nih.gov/pubmed/35418484
http://dx.doi.org/10.1136/jitc-2022-004601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014099/
https://www.ncbi.nlm.nih.gov/pubmed/35418484
http://dx.doi.org/10.1136/jitc-2022-004601

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