Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2α(Lys198Arg)

Specific de novo mutations in the CSNK2A1 gene, which encodes CK2α, the catalytic subunit of protein kinase CK2, are considered as causative for the Okur-Chung neurodevelopmental syndrome (OCNDS). OCNDS is a rare congenital disease with a high phenotypic diversity ranging from neurodevelopmental dis...

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Detalles Bibliográficos
Autores principales: Werner, Christian, Gast, Alexander, Lindenblatt, Dirk, Nickelsen, Anna, Niefind, Karsten, Jose, Joachim, Hochscherf, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014129/
https://www.ncbi.nlm.nih.gov/pubmed/35445078
http://dx.doi.org/10.3389/fmolb.2022.831693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014129/
https://www.ncbi.nlm.nih.gov/pubmed/35445078
http://dx.doi.org/10.3389/fmolb.2022.831693

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