Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease

The Glioma-associated oncogene (Gli) family members of zinc finger DNA-binding proteins are core effectors of Sonic hedgehog (SHH) signaling pathway. Studies in model organisms have identified that the Gli genes play critical roles during organ development, including the heart, brain, kidneys, etc....

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Detalles Bibliográficos
Autores principales: Peng, Rui, Li, Binbin, Chen, Shuxia, Shi, Zhiwen, Yu, Liwei, Gao, Yunqian, Yang, Xueyan, Lu, Lei, Wang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014293/
https://www.ncbi.nlm.nih.gov/pubmed/35445092
http://dx.doi.org/10.3389/fcvm.2022.798033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014293/
https://www.ncbi.nlm.nih.gov/pubmed/35445092
http://dx.doi.org/10.3389/fcvm.2022.798033

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