An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition

OBJECTIVE: Profound metabolic alterations characterize cancer development and, beyond glucose addiction, amino acid (AA) dependency is now recognized as a hallmark of tumour growth. Therefore, targeting the metabolic addiction of tumours by reprogramming their substrate utilization is an attractive...

Descripción completa

Detalles Bibliográficos
Autores principales: Ragni, Maurizio, Ruocco, Chiara, Tedesco, Laura, Carruba, Michele O., Valerio, Alessandra, Nisoli, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014392/
https://www.ncbi.nlm.nih.gov/pubmed/35367410
http://dx.doi.org/10.1016/j.molmet.2022.101478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014392/
https://www.ncbi.nlm.nih.gov/pubmed/35367410
http://dx.doi.org/10.1016/j.molmet.2022.101478

Ejemplares similares