Cargando…

An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition

OBJECTIVE: Profound metabolic alterations characterize cancer development and, beyond glucose addiction, amino acid (AA) dependency is now recognized as a hallmark of tumour growth. Therefore, targeting the metabolic addiction of tumours by reprogramming their substrate utilization is an attractive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ragni, Maurizio, Ruocco, Chiara, Tedesco, Laura, Carruba, Michele O., Valerio, Alessandra, Nisoli, Enzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014392/ https://www.ncbi.nlm.nih.gov/pubmed/35367410 http://dx.doi.org/10.1016/j.molmet.2022.101478

Ejemplares similares

A Special Amino-Acid Formula Tailored to Boosting Cell Respiration Prevents Mitochondrial Dysfunction and Oxidative Stress Caused by Doxorubicin in Mouse Cardiomyocytes
por: Tedesco, Laura, et al.
Publicado: (2020)

Efficacy and tolerability of a specific blend of amino acids in patients with anorexia nervosa treated in a hospital setting: study protocol for a randomized controlled trial
por: Dalle Grave, Riccardo, et al.
Publicado: (2023)

An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts
por: Ragni, Maurizio, et al.
Publicado: (2023)

Role of Portion Size in the Context of a Healthy, Balanced Diet: A Case Study of European Countries
por: Carruba, Michele O., et al.
Publicado: (2023)

A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult
por: Ragni, Maurizio, et al.
Publicado: (2023)

Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways
por: Tedesco, Laura, et al.
Publicado: (2010)

Amino Acids in Cancer and Cachexia: An Integrated View
por: Ragni, Maurizio, et al.
Publicado: (2022)

Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control
por: Bifari, Francesco, et al.
Publicado: (2017)

Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction
por: Ragni, Maurizio, et al.
Publicado: (2023)

Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney
por: Corsetti, Giovanni, et al.
Publicado: (2014)

COVID-19 and Hartnup disease: an affair of intestinal amino acid malabsorption
por: Nisoli, Enzo, et al.
Publicado: (2020)

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
por: Valerio, Alessandra, et al.
Publicado: (2011)

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response
por: Camacho, Alberto, et al.
Publicado: (2012)

Depletion of Luminal Pyridine Nucleotides in the Endoplasmic Reticulum Activates Autophagy with the Involvement of mTOR Pathway
por: Kapuy, Orsolya, et al.
Publicado: (2013)

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy
por: Holczer, Marianna, et al.
Publicado: (2016)

mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types
por: Koscielny, Alicja, et al.
Publicado: (2021)

Paracetamol: A Review of Guideline Recommendations
por: Freo, Ulderico, et al.
Publicado: (2021)

An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response
por: Chang, Jae-Woong, et al.
Publicado: (2018)

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
por: Karali, Evdoxia, et al.
Publicado: (2014)

mTOR pathway mediates endoplasmic reticulum stress-induced CD4(+) T cell apoptosis in septic mice
por: Bai, Guangxu, et al.
Publicado: (2022)

Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes
por: Tedesco, Laura, et al.
Publicado: (2008)

Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through Akt/mTOR Signaling
por: Kim, Jongwan, et al.
Publicado: (2015)

mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4(+) T Cell Apoptosis Mediated by ROS in Septic Immunosuppression
por: Wang, Hao, et al.
Publicado: (2022)

Childhood obesity, overweight and underweight: a study in primary schools in Milan
por: Bracale, Renata, et al.
Publicado: (2013)

Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
por: Ruocco, Chiara, et al.
Publicado: (2020)

Defining the dance: quantification and classification of endoplasmic reticulum dynamics
por: Pain, Charlotte, et al.
Publicado: (2020)

mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study
por: Kapuy, Orsolya, et al.
Publicado: (2014)

α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway
por: Hasanain, M, et al.
Publicado: (2015)

Nitric oxide, interorganelle communication, and energy flow: a novel route to slow aging
por: Valerio, Alessandra, et al.
Publicado: (2015)

Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress
por: Wu, Jianjun, et al.
Publicado: (2021)

Inadequate BiP availability defines endoplasmic reticulum stress
por: Vitale, Milena, et al.
Publicado: (2019)

Comparison of Protein- or Amino Acid-Based Supplements in the Rehabilitation of Men with Severe Obesity: A Randomized Controlled Pilot Study
por: Brunani, Amelia, et al.
Publicado: (2023)

Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress
por: Zhou, Yong, et al.
Publicado: (2014)

Ca(2+)-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling
por: Yu, Zhihua, et al.
Publicado: (2018)

Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2
por: Montori-Grau, Marta, et al.
Publicado: (2022)

Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells
por: Hu, Huiling, et al.
Publicado: (2022)

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
por: Renna, Maurizio
Publicado: (2016)

Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress
por: Holczer, Marianna, et al.
Publicado: (2018)

Mechanisms of amino acid sensing in mTOR signaling pathway
por: Kim, Eunjung
Publicado: (2009)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Cannot write session to /tmp/vufind_sessions/sess_mmh6uqoeqaun1rg7pfntqkki5h