Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells

[Image: see text] Class I histone deacetylase (HDAC) enzymes 1, 2, and 3 organize chromatin as the catalytic subunits within seven distinct multiprotein corepressor complexes and are established drug targets. We report optimization studies of benzamide-based Von Hippel–Lindau (VHL) E3-ligase proteol...

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Detalles Bibliográficos
Autores principales: Smalley, Joshua P., Baker, India M., Pytel, Wiktoria A., Lin, Li-Ying, Bowman, Karen J., Schwabe, John W. R., Cowley, Shaun M., Hodgkinson, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014412/
https://www.ncbi.nlm.nih.gov/pubmed/35293758
http://dx.doi.org/10.1021/acs.jmedchem.1c02179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014412/
https://www.ncbi.nlm.nih.gov/pubmed/35293758
http://dx.doi.org/10.1021/acs.jmedchem.1c02179

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