Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

[Image: see text] In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant protein. These defects can be targeted with pharmacological agents named potentiators and correctors...

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Detalles Bibliográficos
Autores principales: Brusa, Irene, Sondo, Elvira, Falchi, Federico, Pedemonte, Nicoletta, Roberti, Marinella, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014417/
https://www.ncbi.nlm.nih.gov/pubmed/35377645
http://dx.doi.org/10.1021/acs.jmedchem.1c01897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014417/
https://www.ncbi.nlm.nih.gov/pubmed/35377645
http://dx.doi.org/10.1021/acs.jmedchem.1c01897

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