Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA

Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation into non-canonical dipeptide repeats, which can...

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Detalles Bibliográficos
Autores principales: Božič, Janja, Motaln, Helena, Janež, Anja Pucer, Markič, Lara, Tripathi, Priyanka, Yamoah, Alfred, Aronica, Eleonora, Lee, Youn-Bok, Heilig, Raphael, Fischer, Roman, Thompson, Andrew J, Goswami, Anand, Rogelj, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014755/
https://www.ncbi.nlm.nih.gov/pubmed/34534264
http://dx.doi.org/10.1093/brain/awab300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014755/
https://www.ncbi.nlm.nih.gov/pubmed/34534264
http://dx.doi.org/10.1093/brain/awab300

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