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Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA
Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation into non-canonical dipeptide repeats, which can...
Autores principales: | Božič, Janja, Motaln, Helena, Janež, Anja Pucer, Markič, Lara, Tripathi, Priyanka, Yamoah, Alfred, Aronica, Eleonora, Lee, Youn-Bok, Heilig, Raphael, Fischer, Roman, Thompson, Andrew J, Goswami, Anand, Rogelj, Boris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014755/ https://www.ncbi.nlm.nih.gov/pubmed/34534264 http://dx.doi.org/10.1093/brain/awab300 |
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