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Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques

Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an addition...

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Autores principales: Deng, Wei, Lv, Qi, Li, Fengdi, Liu, Jiangning, Song, Zhiqi, Qi, Feifei, Wei, Qiang, Yu, Pin, Liu, Mingya, Zhou, Shasha, Zhang, Yaqing, Gao, Hong, Wang, Nan, Jia, Zijing, Gao, Kai, Liu, Jiayi, Xiao, Chong, Shang, Haiquan, Wang, Xiangxi, Bao, Linlin, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014776/
https://www.ncbi.nlm.nih.gov/pubmed/35436986
http://dx.doi.org/10.1038/s41392-022-00979-z
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author Deng, Wei
Lv, Qi
Li, Fengdi
Liu, Jiangning
Song, Zhiqi
Qi, Feifei
Wei, Qiang
Yu, Pin
Liu, Mingya
Zhou, Shasha
Zhang, Yaqing
Gao, Hong
Wang, Nan
Jia, Zijing
Gao, Kai
Liu, Jiayi
Xiao, Chong
Shang, Haiquan
Wang, Xiangxi
Bao, Linlin
Qin, Chuan
author_facet Deng, Wei
Lv, Qi
Li, Fengdi
Liu, Jiangning
Song, Zhiqi
Qi, Feifei
Wei, Qiang
Yu, Pin
Liu, Mingya
Zhou, Shasha
Zhang, Yaqing
Gao, Hong
Wang, Nan
Jia, Zijing
Gao, Kai
Liu, Jiayi
Xiao, Chong
Shang, Haiquan
Wang, Xiangxi
Bao, Linlin
Qin, Chuan
author_sort Deng, Wei
collection PubMed
description Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron. These results suggest that sequential immunization of inactivated vaccines or polyvalent vaccines could be a potentially effective countermeasure against newly emerging variants.
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spelling pubmed-90147762022-04-19 Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques Deng, Wei Lv, Qi Li, Fengdi Liu, Jiangning Song, Zhiqi Qi, Feifei Wei, Qiang Yu, Pin Liu, Mingya Zhou, Shasha Zhang, Yaqing Gao, Hong Wang, Nan Jia, Zijing Gao, Kai Liu, Jiayi Xiao, Chong Shang, Haiquan Wang, Xiangxi Bao, Linlin Qin, Chuan Signal Transduct Target Ther Article Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron. These results suggest that sequential immunization of inactivated vaccines or polyvalent vaccines could be a potentially effective countermeasure against newly emerging variants. Nature Publishing Group UK 2022-04-18 /pmc/articles/PMC9014776/ /pubmed/35436986 http://dx.doi.org/10.1038/s41392-022-00979-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Deng, Wei
Lv, Qi
Li, Fengdi
Liu, Jiangning
Song, Zhiqi
Qi, Feifei
Wei, Qiang
Yu, Pin
Liu, Mingya
Zhou, Shasha
Zhang, Yaqing
Gao, Hong
Wang, Nan
Jia, Zijing
Gao, Kai
Liu, Jiayi
Xiao, Chong
Shang, Haiquan
Wang, Xiangxi
Bao, Linlin
Qin, Chuan
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title_full Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title_fullStr Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title_full_unstemmed Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title_short Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
title_sort sequential immunizations confer cross-protection against variants of sars-cov-2, including omicron in rhesus macaques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014776/
https://www.ncbi.nlm.nih.gov/pubmed/35436986
http://dx.doi.org/10.1038/s41392-022-00979-z
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