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Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an addition...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014776/ https://www.ncbi.nlm.nih.gov/pubmed/35436986 http://dx.doi.org/10.1038/s41392-022-00979-z |
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author | Deng, Wei Lv, Qi Li, Fengdi Liu, Jiangning Song, Zhiqi Qi, Feifei Wei, Qiang Yu, Pin Liu, Mingya Zhou, Shasha Zhang, Yaqing Gao, Hong Wang, Nan Jia, Zijing Gao, Kai Liu, Jiayi Xiao, Chong Shang, Haiquan Wang, Xiangxi Bao, Linlin Qin, Chuan |
author_facet | Deng, Wei Lv, Qi Li, Fengdi Liu, Jiangning Song, Zhiqi Qi, Feifei Wei, Qiang Yu, Pin Liu, Mingya Zhou, Shasha Zhang, Yaqing Gao, Hong Wang, Nan Jia, Zijing Gao, Kai Liu, Jiayi Xiao, Chong Shang, Haiquan Wang, Xiangxi Bao, Linlin Qin, Chuan |
author_sort | Deng, Wei |
collection | PubMed |
description | Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron. These results suggest that sequential immunization of inactivated vaccines or polyvalent vaccines could be a potentially effective countermeasure against newly emerging variants. |
format | Online Article Text |
id | pubmed-9014776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90147762022-04-19 Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques Deng, Wei Lv, Qi Li, Fengdi Liu, Jiangning Song, Zhiqi Qi, Feifei Wei, Qiang Yu, Pin Liu, Mingya Zhou, Shasha Zhang, Yaqing Gao, Hong Wang, Nan Jia, Zijing Gao, Kai Liu, Jiayi Xiao, Chong Shang, Haiquan Wang, Xiangxi Bao, Linlin Qin, Chuan Signal Transduct Target Ther Article Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron. These results suggest that sequential immunization of inactivated vaccines or polyvalent vaccines could be a potentially effective countermeasure against newly emerging variants. Nature Publishing Group UK 2022-04-18 /pmc/articles/PMC9014776/ /pubmed/35436986 http://dx.doi.org/10.1038/s41392-022-00979-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Deng, Wei Lv, Qi Li, Fengdi Liu, Jiangning Song, Zhiqi Qi, Feifei Wei, Qiang Yu, Pin Liu, Mingya Zhou, Shasha Zhang, Yaqing Gao, Hong Wang, Nan Jia, Zijing Gao, Kai Liu, Jiayi Xiao, Chong Shang, Haiquan Wang, Xiangxi Bao, Linlin Qin, Chuan Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title | Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title_full | Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title_fullStr | Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title_full_unstemmed | Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title_short | Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques |
title_sort | sequential immunizations confer cross-protection against variants of sars-cov-2, including omicron in rhesus macaques |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014776/ https://www.ncbi.nlm.nih.gov/pubmed/35436986 http://dx.doi.org/10.1038/s41392-022-00979-z |
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