Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses

Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit maturation, provoking these enduring vulnerabilities. We find that ELA increases functional excitatory synapses ont...

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Detalles Bibliográficos
Autores principales: Bolton, Jessica L., Short, Annabel K., Othy, Shivashankar, Kooiker, Cassandra L., Shao, Manlin, Gunn, Benjamin G., Beck, Jaclyn, Bai, Xinglong, Law, Stephanie M., Savage, Julie C., Lambert, Jeremy J., Belelli, Delia, Tremblay, Marie-Ève, Cahalan, Michael D., Baram, Tallie Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014810/
https://www.ncbi.nlm.nih.gov/pubmed/35354026
http://dx.doi.org/10.1016/j.celrep.2022.110600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014810/
https://www.ncbi.nlm.nih.gov/pubmed/35354026
http://dx.doi.org/10.1016/j.celrep.2022.110600

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