Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones

[Image: see text] Venezuelan and eastern equine encephalitis viruses are disease-causing, neuropathic pathogens with no approved treatment options in humans. While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-tre...

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Detalles Bibliográficos
Autores principales: Ryan, Michael C., Kim, Eunjung, Cao, Xufeng, Reichard, Walter, Ogorek, Tyler J., Das, Pronay, Jonsson, Colleen B., Baudry, Jerome, Chung, Donghoon, Golden, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014857/
https://www.ncbi.nlm.nih.gov/pubmed/35450382
http://dx.doi.org/10.1021/acsmedchemlett.1c00539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014857/
https://www.ncbi.nlm.nih.gov/pubmed/35450382
http://dx.doi.org/10.1021/acsmedchemlett.1c00539

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