Occurrence of a novel cleavage site for cathepsin G adjacent to the polybasic sequence within the proteolytically sensitive activation loop of the SARS-CoV-2 Omicron variant: The amino acid substitution N679K and P681H of the spike protein

The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are secreted by activated neutrophils as a part of the innate immune response against invading pathogens. However, these serine proteases might be adopted by viruses to medi...

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Detalles Bibliográficos
Autores principales: Mustafa, Zhadyra, Kalbacher, Hubert, Burster, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015119/
https://www.ncbi.nlm.nih.gov/pubmed/35436320
http://dx.doi.org/10.1371/journal.pone.0264723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015119/
https://www.ncbi.nlm.nih.gov/pubmed/35436320
http://dx.doi.org/10.1371/journal.pone.0264723

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