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A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal

BACKGROUND: Microglia have recently been implicated in opioid dependence and withdrawal. Mu opioid receptors are expressed in microglia, and microglia form intimate connections with nearby neurons. Accordingly, opioids have both direct (mu opioid receptor mediated) and indirect (neuron interaction m...

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Detalles Bibliográficos
Autores principales: Coffey, Kevin R., Lesiak, Atom J., Marx, Ruby E., Vo, Emily K., Garden, Gwenn A., Neumaier, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015218/
https://www.ncbi.nlm.nih.gov/pubmed/35441155
http://dx.doi.org/10.1016/j.bpsgos.2021.07.011