Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease

The two SARS‐CoV‐2 proteases, i. e. the main protease (M(pro)) and the papain‐like protease (PL(pro)), which hydrolyze the viral polypeptide chain giving functional non‐structural proteins, are essential for viral replication and are medicinal chemistry targets. We report a high‐throughput mass spec...

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Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Kamps, Jos J. A. G., Lukacik, Petra, Strain‐Damerell, Claire, Zhao, Yilin, Tumber, Anthony, Malla, Tika R., Orville, Allen M., Walsh, Martin A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015526/
https://www.ncbi.nlm.nih.gov/pubmed/35085423
http://dx.doi.org/10.1002/cmdc.202200016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015526/
https://www.ncbi.nlm.nih.gov/pubmed/35085423
http://dx.doi.org/10.1002/cmdc.202200016

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