First stereoselective total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid, the biosynthetic precursor of resolvins D3 and D4

The first total convergent synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid (1) is described. The reported synthesis led to confirmation of the native epoxydocosahexaenoic acid as the biosynthetic precursor of lipid mediators resolvin D3 and resolvin...

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Detalles Bibliográficos
Autores principales: Nshimiyimana, Robert, Lam, Ting Fung, Aggarwal, Shubhangi, Serhan, Charles N., Petasis, Nicos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015894/
https://www.ncbi.nlm.nih.gov/pubmed/35481084
http://dx.doi.org/10.1039/d2ra01537d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015894/
https://www.ncbi.nlm.nih.gov/pubmed/35481084
http://dx.doi.org/10.1039/d2ra01537d

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