Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson’s Disease

Stearoyl-CoA desaturase (SCD) is a potential therapeutic target for Parkinson’s and related neurodegenerative diseases. SCD inhibition ameliorates neuronal toxicity caused by aberrant α-synuclein, a lipid-binding protein implicated in Parkinson’s disease. Its inhibition depletes monounsaturated fatt...

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Detalles Bibliográficos
Autores principales: Tardiff, Daniel F., Lucas, Matthew, Wrona, Iwona, Chang, Belle, Chung, Chee Yeun, Le Bourdonnec, Bertrand, Rhodes, Kenneth J., Scannevin, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015998/
https://www.ncbi.nlm.nih.gov/pubmed/35060064
http://dx.doi.org/10.1007/s12035-021-02695-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015998/
https://www.ncbi.nlm.nih.gov/pubmed/35060064
http://dx.doi.org/10.1007/s12035-021-02695-1

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