Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage. In this work, we have characterized the Trypanosoma brucei ITPase ortholog (TbITPA). Recombinant TbITPA efficiently...

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Detalles Bibliográficos
Autores principales: Vidal, Antonio E., Yagüe-Capilla, Miriam, Martínez-Arribas, Blanca, García-Caballero, Daniel, Ruiz-Pérez, Luis M., González-Pacanowska, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016069/
https://www.ncbi.nlm.nih.gov/pubmed/35436992
http://dx.doi.org/10.1038/s41598-022-10149-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016069/
https://www.ncbi.nlm.nih.gov/pubmed/35436992
http://dx.doi.org/10.1038/s41598-022-10149-4

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