Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress

In the tumor microenvironment, cancer cells experience hypoxia resulting in the accumulation of misfolded/unfolded proteins largely in the endoplasmic reticulum (ER). Consequently, ER proteotoxicity elicits unfolded protein response (UPR) as an adaptive mechanism to resolve ER stress. In addition to...

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Detalles Bibliográficos
Autores principales: Chipurupalli, Sandhya, Ganesan, Raja, Martini, Giulia, Mele, Luigi, Reggio, Alessio, Esposito, Marianna, Kannan, Elango, Namasivayam, Vigneshwaran, Grumati, Paolo, Desiderio, Vincenzo, Robinson, Nirmal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016075/
https://www.ncbi.nlm.nih.gov/pubmed/35436985
http://dx.doi.org/10.1038/s41419-022-04813-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016075/
https://www.ncbi.nlm.nih.gov/pubmed/35436985
http://dx.doi.org/10.1038/s41419-022-04813-w

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