Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection

Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane pr...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Radvak, Peter, Lee, Juhyung, Xu, Yue, Cao-Dao, Vivian, Xu, Miao, Zheng, Wei, Chen, Catherine Z., Xie, Hang, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016215/
https://www.ncbi.nlm.nih.gov/pubmed/35440680
http://dx.doi.org/10.1038/s41598-022-10293-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016215/
https://www.ncbi.nlm.nih.gov/pubmed/35440680
http://dx.doi.org/10.1038/s41598-022-10293-x

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