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Composite endpoint for ALS clinical trials based on patient preference: Patient-Ranked Order of Function (PROOF)
BACKGROUND: Patients with amyotrophic lateral sclerosis (ALS) show considerable variation in symptoms. Treatments targeting an overall improvement in symptomatology may not address what the majority of patients consider to be most important. Here, we propose a composite endpoint for ALS clinical tri...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Publishing Group
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016230/ https://www.ncbi.nlm.nih.gov/pubmed/34921121 http://dx.doi.org/10.1136/jnnp-2021-328194 |