miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non–Small Cell Lung Cancer Cells by Targeting USP37

PURPOSE: With the identification of epidermal growth factor receptor (EGFR) mutations in non–small cell lung cancer (NSCLC) cells, EGFR–tyrosine kinase inhibitors (TKIs) are being used widely as the first-line of treatment in NSCLC. These inhibitors block auto-phosphorylation of activated EGFR by co...

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Detalles Bibliográficos
Autores principales: Kim, Mi Seong, Kim, So Hui, Yang, Sei Hoon, Kim, Min Seuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016303/
https://www.ncbi.nlm.nih.gov/pubmed/34352998
http://dx.doi.org/10.4143/crt.2021.622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016303/
https://www.ncbi.nlm.nih.gov/pubmed/34352998
http://dx.doi.org/10.4143/crt.2021.622

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