Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

Post‐translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neurodegenerative disorders. The major aggregating protein in amyotrophic lateral sclerosis and frontotemporal dementia, the RNA‐binding protein TAR DNA‐b...

Descripción completa

Detalles Bibliográficos
Autores principales: Gruijs da Silva, Lara A, Simonetti, Francesca, Hutten, Saskia, Riemenschneider, Henrick, Sternburg, Erin L, Pietrek, Lisa M, Gebel, Jakob, Dötsch, Volker, Edbauer, Dieter, Hummer, Gerhard, Stelzl, Lukas S, Dormann, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016352/
https://www.ncbi.nlm.nih.gov/pubmed/35112738
http://dx.doi.org/10.15252/embj.2021108443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016352/
https://www.ncbi.nlm.nih.gov/pubmed/35112738
http://dx.doi.org/10.15252/embj.2021108443

Ejemplares similares