Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

[Image: see text] Inhibitors of the proprotein convertase furin might serve as broad-spectrum antiviral therapeutics. High cellular potency and antiviral activity against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported for (3,5-dichlorophenyl)pyridine-derived furin inhibitor...

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Detalles Bibliográficos
Autores principales: Dahms, Sven O., Schnapp, Gisela, Winter, Martin, Büttner, Frank H., Schlepütz, Marco, Gnamm, Christian, Pautsch, Alexander, Brandstetter, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016704/
https://www.ncbi.nlm.nih.gov/pubmed/35377598
http://dx.doi.org/10.1021/acschembio.2c00103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016704/
https://www.ncbi.nlm.nih.gov/pubmed/35377598
http://dx.doi.org/10.1021/acschembio.2c00103

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