Cargando…

Interconversion between Serum Amyloid A Native and Fibril Conformations

[Image: see text] Overexpression of serum amyloid A (SAA) can lead to a form of amyloidosis where the fibrils are made of SAA fragments, most often SAA(1–76). Using Replica Exchange with Tunneling, we study the conversion of a SAA(1–76) chain between the folded conformation and a fibril conformation...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasar, Fatih, Sheridan, Miranda S., Hansmann, Ulrich H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016813/
https://www.ncbi.nlm.nih.gov/pubmed/35449919
http://dx.doi.org/10.1021/acsomega.2c00566