Cargando…
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers
Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program in cancer cells. To shed light on the underlying molecular mechanism driving this process,...
Autores principales: | Lemma, Roza Berhanu, Fleischer, Thomas, Martinsen, Emily, Ledsaak, Marit, Kristensen, Vessela, Eskeland, Ragnhild, Gabrielsen, Odd Stokke, Mathelier, Anthony |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016969/ https://www.ncbi.nlm.nih.gov/pubmed/35440061 http://dx.doi.org/10.1186/s13072-022-00444-9 |
Ejemplares similares
-
MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape
por: Lemma, Roza Berhanu, et al.
Publicado: (2023) -
Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB
por: Lemma, Roza B., et al.
Publicado: (2021) -
The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation
por: Fuglerud, Bettina M., et al.
Publicado: (2018) -
A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function
por: Fuglerud, Bettina M., et al.
Publicado: (2017) -
Dissecting the transactivation domain (tAD) of the transcription factor c‐Myb to assess recent models of tAD function
por: Næs, Guro, et al.
Publicado: (2020)