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Discovery and validation of human genomic safe harbor sites for gene and cell therapies
Existing approaches to therapeutic gene transfer are marred by the transient nature of gene expression following non-integrative gene delivery and by safety concerns due to the random mechanism of viral-mediated genomic insertions. The disadvantages of these methods encourage future research in iden...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017210/ https://www.ncbi.nlm.nih.gov/pubmed/35474867 http://dx.doi.org/10.1016/j.crmeth.2021.100154 |