Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis

We previously identified a series of triazolopyrimidines with antitubercular activity. We determined that Mycobacterium tuberculosis strains with mutations in QcrB, a subunit of the cytochrome bcc-aa3 supercomplex, were resistant. A cytochrome bd oxidase deletion strain was more sensitive to this se...

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Detalles Bibliográficos
Autores principales: Shelton, Catherine, McNeil, Matthew, Allen, Renee, Flint, Lindsay, Russell, Dara, Berube, Bryan, Korkegian, Aaron, Ovechkina, Yulia, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017309/
https://www.ncbi.nlm.nih.gov/pubmed/35262374
http://dx.doi.org/10.1128/aac.02041-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017309/
https://www.ncbi.nlm.nih.gov/pubmed/35262374
http://dx.doi.org/10.1128/aac.02041-21

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