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Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis

We previously identified a series of triazolopyrimidines with antitubercular activity. We determined that Mycobacterium tuberculosis strains with mutations in QcrB, a subunit of the cytochrome bcc-aa3 supercomplex, were resistant. A cytochrome bd oxidase deletion strain was more sensitive to this se...

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Detalles Bibliográficos
Autores principales:	Shelton, Catherine, McNeil, Matthew, Allen, Renee, Flint, Lindsay, Russell, Dara, Berube, Bryan, Korkegian, Aaron, Ovechkina, Yulia, Parish, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017309/ https://www.ncbi.nlm.nih.gov/pubmed/35262374 http://dx.doi.org/10.1128/aac.02041-21

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