Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants

Fostemsavir is a prodrug of temsavir, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4(+) T cells with demonstrated efficacy in phase 2 and 3. Temsavir is a P-glycoprotein and breast cancer resistance protein (BCRP)...

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Detalles Bibliográficos
Autores principales: Moore, Katy, Thakkar, Nilay, Magee, Mindy, Sevinsky, Heather, Vakkalagadda, Blisse, Lubin, Susan, Llamoso, Cyril, Ackerman, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017385/
https://www.ncbi.nlm.nih.gov/pubmed/35315687
http://dx.doi.org/10.1128/aac.02251-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017385/
https://www.ncbi.nlm.nih.gov/pubmed/35315687
http://dx.doi.org/10.1128/aac.02251-21

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