Integrative Analysis of Pharmacokinetic and Metabolomic Profiles for Predicting Metabolic Phenotype and Drug Exposure Caused by Sotorasib in Rats

Sotorasib is a novel targeted inhibitor of Kirsten rat sarcoma (KRAS) (G12C) that has shown exciting tumor-suppressing effects not only for single targeted agents but also for combination with immune checkpoint inhibitors. However, no integrative analysis of the pharmacokinetics (PK) and pharmacomet...

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Detalles Bibliográficos
Autores principales: Du, Ping, Liu, Lihong, Hu, Ting, An, Zhuoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017425/
https://www.ncbi.nlm.nih.gov/pubmed/35449573
http://dx.doi.org/10.3389/fonc.2022.778035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017425/
https://www.ncbi.nlm.nih.gov/pubmed/35449573
http://dx.doi.org/10.3389/fonc.2022.778035

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