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Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Effective presentation of antigens by HLA class I molecules to CD8(+) T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multi-omic technology to generate a unified ex vivo characterization of the CD8(+) T cell respons...

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Autores principales: Francis, Joshua M., Leistritz-Edwards, Del, Dunn, Augustine, Tarr, Christina, Lehman, Jesse, Dempsey, Conor, Hamel, Andrew, Rayon, Violeta, Liu, Gang, Wang, Yuntong, Wille, Marcos, Durkin, Melissa, Hadley, Kane, Sheena, Aswathy, Roscoe, Benjamin, Ng, Mark, Rockwell, Graham, Manto, Margaret, Gienger, Elizabeth, Nickerson, Joshua, Moarefi, Amir, Noble, Michael, Malia, Thomas, Bardwell, Philip D., Gordon, William, Swain, Joanna, Skoberne, Mojca, Sauer, Karsten, Harris, Tim, Goldrath, Ananda W., Shalek, Alex K., Coyle, Anthony J., Benoist, Christophe, Pregibon, Daniel C., Jilg, Nikolaus, Li, Jonathan, Rosenthal, Alex, Wong, Colline, Daley, George, Golan, David, Heller, Howard, Sharpe, Arlene, Abayneh, Betelihem A., Allen, Patrick, Antille, Diane, Armstrong, Katrina, Boyce, Siobhan, Braley, Joan, Branch, Karen, Broderick, Katherine, Carney, Julia, Chan, Andrew, Davidson, Susan, Dougan, Michael, Drew, David, Elliman, Ashley, Flaherty, Keith, Flannery, Jeanne, Forde, Pamela, Gettings, Elise, Griffin, Amanda, Grimmel, Sheila, Grinke, Kathleen, Hall, Kathryn, Healy, Meg, Henault, Deborah, Holland, Grace, Kayitesi, Chantal, LaValle, Vlasta, Lu, Yuting, Luthern, Sarah, Schneider, Jordan Marchewka, Martino, Brittani, McNamara, Roseann, Nambu, Christian, Nelson, Susan, Noone, Marjorie, Ommerborn, Christine, Pacheco, Lois Chris, Phan, Nicole, Porto, Falisha A, Ryan, Edward, Selleck, Kathleen, Slaughenhaupt, Sue, Sheppard, Kimberly Smith, Suschana, Elizabeth, Wilson, Vivine, Carrington, Mary, Martin, Maureen, Yuki, Yuko, Alter, Galit, Balazs, Alejandro, Bals, Julia, Barbash, Max, Bartsch, Yannic, Boucau, Julie, Chevalier, Josh, Chowdhury, Fatema, DeMers, Edward, Einkauf, Kevin, Fallon, Jon, Fedirko, Liz, Finn, Kelsey, Garcia-Broncano, Pilar, Ghebremichael, Musie S., Hartana, Ciputra, Jiang, Chenyang, Judge, Kelly, Kaplonek, Paulina, Karpell, Marshall, Lai, Peggy, Lam, Evan C., Lefteri, Kristina, Lian, Xiaodong, Lichterfeld, Mathias, Lingwood, Daniel, Liu, Hang, Liu, Jinqing, Ly, Natasha, Hill, Zachary Manickas, Michell, Ashlin, Millstrom, Ilan, Miranda, Noah, O'Callaghan, Claire, Osborn, Matthew, Pillai, Shiv, Rassadkina, Yelizaveta, Reissis, Alexandra, Ruzicka, Francis, Seiger, Kyra, Sessa, Libera, Sharr, Christianne, Shin, Sally, Singh, Nishant, Sun, Weiwei, Sun, Xiaoming, Ticheli, Hannah, Trocha-Piechocka, Alicja, Walker, Bruce, Worrall, Daniel, Yu, Xu G., Zhu, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017864/
https://www.ncbi.nlm.nih.gov/pubmed/34793243
http://dx.doi.org/10.1126/sciimmunol.abk3070