Cargando…
Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
Effective presentation of antigens by HLA class I molecules to CD8(+) T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multi-omic technology to generate a unified ex vivo characterization of the CD8(+) T cell respons...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017864/ https://www.ncbi.nlm.nih.gov/pubmed/34793243 http://dx.doi.org/10.1126/sciimmunol.abk3070 |
| _version_ | 1784688872505999360 |
|---|---|
| author | Francis, Joshua M. Leistritz-Edwards, Del Dunn, Augustine Tarr, Christina Lehman, Jesse Dempsey, Conor Hamel, Andrew Rayon, Violeta Liu, Gang Wang, Yuntong Wille, Marcos Durkin, Melissa Hadley, Kane Sheena, Aswathy Roscoe, Benjamin Ng, Mark Rockwell, Graham Manto, Margaret Gienger, Elizabeth Nickerson, Joshua Moarefi, Amir Noble, Michael Malia, Thomas Bardwell, Philip D. Gordon, William Swain, Joanna Skoberne, Mojca Sauer, Karsten Harris, Tim Goldrath, Ananda W. Shalek, Alex K. Coyle, Anthony J. Benoist, Christophe Pregibon, Daniel C. Jilg, Nikolaus Li, Jonathan Rosenthal, Alex Wong, Colline Daley, George Golan, David Heller, Howard Sharpe, Arlene Abayneh, Betelihem A. Allen, Patrick Antille, Diane Armstrong, Katrina Boyce, Siobhan Braley, Joan Branch, Karen Broderick, Katherine Carney, Julia Chan, Andrew Davidson, Susan Dougan, Michael Drew, David Elliman, Ashley Flaherty, Keith Flannery, Jeanne Forde, Pamela Gettings, Elise Griffin, Amanda Grimmel, Sheila Grinke, Kathleen Hall, Kathryn Healy, Meg Henault, Deborah Holland, Grace Kayitesi, Chantal LaValle, Vlasta Lu, Yuting Luthern, Sarah Schneider, Jordan Marchewka Martino, Brittani McNamara, Roseann Nambu, Christian Nelson, Susan Noone, Marjorie Ommerborn, Christine Pacheco, Lois Chris Phan, Nicole Porto, Falisha A Ryan, Edward Selleck, Kathleen Slaughenhaupt, Sue Sheppard, Kimberly Smith Suschana, Elizabeth Wilson, Vivine Carrington, Mary Martin, Maureen Yuki, Yuko Alter, Galit Balazs, Alejandro Bals, Julia Barbash, Max Bartsch, Yannic Boucau, Julie Carrington, Mary Chevalier, Josh Chowdhury, Fatema DeMers, Edward Einkauf, Kevin Fallon, Jon Fedirko, Liz Finn, Kelsey Garcia-Broncano, Pilar Ghebremichael, Musie S. Hartana, Ciputra Jiang, Chenyang Judge, Kelly Kaplonek, Paulina Karpell, Marshall Lai, Peggy Lam, Evan C. Lefteri, Kristina Lian, Xiaodong Lichterfeld, Mathias Lingwood, Daniel Liu, Hang Liu, Jinqing Ly, Natasha Hill, Zachary Manickas Michell, Ashlin Millstrom, Ilan Miranda, Noah O'Callaghan, Claire Osborn, Matthew Pillai, Shiv Rassadkina, Yelizaveta Reissis, Alexandra Ruzicka, Francis Seiger, Kyra Sessa, Libera Sharr, Christianne Shin, Sally Singh, Nishant Sun, Weiwei Sun, Xiaoming Ticheli, Hannah Trocha-Piechocka, Alicja Walker, Bruce Worrall, Daniel Yu, Xu G. Zhu, Alex |
| author_facet | Francis, Joshua M. Leistritz-Edwards, Del Dunn, Augustine Tarr, Christina Lehman, Jesse Dempsey, Conor Hamel, Andrew Rayon, Violeta Liu, Gang Wang, Yuntong Wille, Marcos Durkin, Melissa Hadley, Kane Sheena, Aswathy Roscoe, Benjamin Ng, Mark Rockwell, Graham Manto, Margaret Gienger, Elizabeth Nickerson, Joshua Moarefi, Amir Noble, Michael Malia, Thomas Bardwell, Philip D. Gordon, William Swain, Joanna Skoberne, Mojca Sauer, Karsten Harris, Tim Goldrath, Ananda W. Shalek, Alex K. Coyle, Anthony J. Benoist, Christophe Pregibon, Daniel C. Jilg, Nikolaus Li, Jonathan Rosenthal, Alex Wong, Colline Daley, George Golan, David Heller, Howard Sharpe, Arlene Abayneh, Betelihem A. Allen, Patrick Antille, Diane Armstrong, Katrina Boyce, Siobhan Braley, Joan Branch, Karen Broderick, Katherine Carney, Julia Chan, Andrew Davidson, Susan Dougan, Michael Drew, David Elliman, Ashley Flaherty, Keith Flannery, Jeanne Forde, Pamela Gettings, Elise Griffin, Amanda Grimmel, Sheila Grinke, Kathleen Hall, Kathryn Healy, Meg Henault, Deborah Holland, Grace Kayitesi, Chantal LaValle, Vlasta Lu, Yuting Luthern, Sarah Schneider, Jordan Marchewka Martino, Brittani McNamara, Roseann Nambu, Christian Nelson, Susan Noone, Marjorie Ommerborn, Christine Pacheco, Lois Chris Phan, Nicole Porto, Falisha A Ryan, Edward Selleck, Kathleen Slaughenhaupt, Sue Sheppard, Kimberly Smith Suschana, Elizabeth Wilson, Vivine Carrington, Mary Martin, Maureen Yuki, Yuko Alter, Galit Balazs, Alejandro Bals, Julia Barbash, Max Bartsch, Yannic Boucau, Julie Carrington, Mary Chevalier, Josh Chowdhury, Fatema DeMers, Edward Einkauf, Kevin Fallon, Jon Fedirko, Liz Finn, Kelsey Garcia-Broncano, Pilar Ghebremichael, Musie S. Hartana, Ciputra Jiang, Chenyang Judge, Kelly Kaplonek, Paulina Karpell, Marshall Lai, Peggy Lam, Evan C. Lefteri, Kristina Lian, Xiaodong Lichterfeld, Mathias Lingwood, Daniel Liu, Hang Liu, Jinqing Ly, Natasha Hill, Zachary Manickas Michell, Ashlin Millstrom, Ilan Miranda, Noah O'Callaghan, Claire Osborn, Matthew Pillai, Shiv Rassadkina, Yelizaveta Reissis, Alexandra Ruzicka, Francis Seiger, Kyra Sessa, Libera Sharr, Christianne Shin, Sally Singh, Nishant Sun, Weiwei Sun, Xiaoming Ticheli, Hannah Trocha-Piechocka, Alicja Walker, Bruce Worrall, Daniel Yu, Xu G. Zhu, Alex |
| author_sort | Francis, Joshua M. |
| collection | PubMed |
| description | Effective presentation of antigens by HLA class I molecules to CD8(+) T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multi-omic technology to generate a unified ex vivo characterization of the CD8(+) T cell response to SARS-CoV-2 across 4 major HLA class I alleles. We found that HLA genotype conditions key features of epitope specificity, TCR α/β sequence diversity, and the utilization of pre-existing SARS-CoV-2 reactive memory T cell pools. Single-cell transcriptomics revealed functionally diverse T cell phenotypes of SARS-CoV-2-reactive T cells, associated with both disease stage and epitope specificity. Our results show that HLA variations significantly influence the CD8(+) T cell repertoire shape and utilization of immune recall upon SARS-CoV-2 infection. |
| format | Online Article Text |
| id | pubmed-9017864 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90178642022-05-16 Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 Francis, Joshua M. Leistritz-Edwards, Del Dunn, Augustine Tarr, Christina Lehman, Jesse Dempsey, Conor Hamel, Andrew Rayon, Violeta Liu, Gang Wang, Yuntong Wille, Marcos Durkin, Melissa Hadley, Kane Sheena, Aswathy Roscoe, Benjamin Ng, Mark Rockwell, Graham Manto, Margaret Gienger, Elizabeth Nickerson, Joshua Moarefi, Amir Noble, Michael Malia, Thomas Bardwell, Philip D. Gordon, William Swain, Joanna Skoberne, Mojca Sauer, Karsten Harris, Tim Goldrath, Ananda W. Shalek, Alex K. Coyle, Anthony J. Benoist, Christophe Pregibon, Daniel C. Jilg, Nikolaus Li, Jonathan Rosenthal, Alex Wong, Colline Daley, George Golan, David Heller, Howard Sharpe, Arlene Abayneh, Betelihem A. Allen, Patrick Antille, Diane Armstrong, Katrina Boyce, Siobhan Braley, Joan Branch, Karen Broderick, Katherine Carney, Julia Chan, Andrew Davidson, Susan Dougan, Michael Drew, David Elliman, Ashley Flaherty, Keith Flannery, Jeanne Forde, Pamela Gettings, Elise Griffin, Amanda Grimmel, Sheila Grinke, Kathleen Hall, Kathryn Healy, Meg Henault, Deborah Holland, Grace Kayitesi, Chantal LaValle, Vlasta Lu, Yuting Luthern, Sarah Schneider, Jordan Marchewka Martino, Brittani McNamara, Roseann Nambu, Christian Nelson, Susan Noone, Marjorie Ommerborn, Christine Pacheco, Lois Chris Phan, Nicole Porto, Falisha A Ryan, Edward Selleck, Kathleen Slaughenhaupt, Sue Sheppard, Kimberly Smith Suschana, Elizabeth Wilson, Vivine Carrington, Mary Martin, Maureen Yuki, Yuko Alter, Galit Balazs, Alejandro Bals, Julia Barbash, Max Bartsch, Yannic Boucau, Julie Carrington, Mary Chevalier, Josh Chowdhury, Fatema DeMers, Edward Einkauf, Kevin Fallon, Jon Fedirko, Liz Finn, Kelsey Garcia-Broncano, Pilar Ghebremichael, Musie S. Hartana, Ciputra Jiang, Chenyang Judge, Kelly Kaplonek, Paulina Karpell, Marshall Lai, Peggy Lam, Evan C. Lefteri, Kristina Lian, Xiaodong Lichterfeld, Mathias Lingwood, Daniel Liu, Hang Liu, Jinqing Ly, Natasha Hill, Zachary Manickas Michell, Ashlin Millstrom, Ilan Miranda, Noah O'Callaghan, Claire Osborn, Matthew Pillai, Shiv Rassadkina, Yelizaveta Reissis, Alexandra Ruzicka, Francis Seiger, Kyra Sessa, Libera Sharr, Christianne Shin, Sally Singh, Nishant Sun, Weiwei Sun, Xiaoming Ticheli, Hannah Trocha-Piechocka, Alicja Walker, Bruce Worrall, Daniel Yu, Xu G. Zhu, Alex Sci Immunol Research Articles Effective presentation of antigens by HLA class I molecules to CD8(+) T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multi-omic technology to generate a unified ex vivo characterization of the CD8(+) T cell response to SARS-CoV-2 across 4 major HLA class I alleles. We found that HLA genotype conditions key features of epitope specificity, TCR α/β sequence diversity, and the utilization of pre-existing SARS-CoV-2 reactive memory T cell pools. Single-cell transcriptomics revealed functionally diverse T cell phenotypes of SARS-CoV-2-reactive T cells, associated with both disease stage and epitope specificity. Our results show that HLA variations significantly influence the CD8(+) T cell repertoire shape and utilization of immune recall upon SARS-CoV-2 infection. American Association for the Advancement of Science 2021-11-18 /pmc/articles/PMC9017864/ /pubmed/34793243 http://dx.doi.org/10.1126/sciimmunol.abk3070 Text en Copyright © 2021, American Association for the Advancement of Science https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Articles Francis, Joshua M. Leistritz-Edwards, Del Dunn, Augustine Tarr, Christina Lehman, Jesse Dempsey, Conor Hamel, Andrew Rayon, Violeta Liu, Gang Wang, Yuntong Wille, Marcos Durkin, Melissa Hadley, Kane Sheena, Aswathy Roscoe, Benjamin Ng, Mark Rockwell, Graham Manto, Margaret Gienger, Elizabeth Nickerson, Joshua Moarefi, Amir Noble, Michael Malia, Thomas Bardwell, Philip D. Gordon, William Swain, Joanna Skoberne, Mojca Sauer, Karsten Harris, Tim Goldrath, Ananda W. Shalek, Alex K. Coyle, Anthony J. Benoist, Christophe Pregibon, Daniel C. Jilg, Nikolaus Li, Jonathan Rosenthal, Alex Wong, Colline Daley, George Golan, David Heller, Howard Sharpe, Arlene Abayneh, Betelihem A. Allen, Patrick Antille, Diane Armstrong, Katrina Boyce, Siobhan Braley, Joan Branch, Karen Broderick, Katherine Carney, Julia Chan, Andrew Davidson, Susan Dougan, Michael Drew, David Elliman, Ashley Flaherty, Keith Flannery, Jeanne Forde, Pamela Gettings, Elise Griffin, Amanda Grimmel, Sheila Grinke, Kathleen Hall, Kathryn Healy, Meg Henault, Deborah Holland, Grace Kayitesi, Chantal LaValle, Vlasta Lu, Yuting Luthern, Sarah Schneider, Jordan Marchewka Martino, Brittani McNamara, Roseann Nambu, Christian Nelson, Susan Noone, Marjorie Ommerborn, Christine Pacheco, Lois Chris Phan, Nicole Porto, Falisha A Ryan, Edward Selleck, Kathleen Slaughenhaupt, Sue Sheppard, Kimberly Smith Suschana, Elizabeth Wilson, Vivine Carrington, Mary Martin, Maureen Yuki, Yuko Alter, Galit Balazs, Alejandro Bals, Julia Barbash, Max Bartsch, Yannic Boucau, Julie Carrington, Mary Chevalier, Josh Chowdhury, Fatema DeMers, Edward Einkauf, Kevin Fallon, Jon Fedirko, Liz Finn, Kelsey Garcia-Broncano, Pilar Ghebremichael, Musie S. Hartana, Ciputra Jiang, Chenyang Judge, Kelly Kaplonek, Paulina Karpell, Marshall Lai, Peggy Lam, Evan C. Lefteri, Kristina Lian, Xiaodong Lichterfeld, Mathias Lingwood, Daniel Liu, Hang Liu, Jinqing Ly, Natasha Hill, Zachary Manickas Michell, Ashlin Millstrom, Ilan Miranda, Noah O'Callaghan, Claire Osborn, Matthew Pillai, Shiv Rassadkina, Yelizaveta Reissis, Alexandra Ruzicka, Francis Seiger, Kyra Sessa, Libera Sharr, Christianne Shin, Sally Singh, Nishant Sun, Weiwei Sun, Xiaoming Ticheli, Hannah Trocha-Piechocka, Alicja Walker, Bruce Worrall, Daniel Yu, Xu G. Zhu, Alex Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title | Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title_full | Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title_fullStr | Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title_full_unstemmed | Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title_short | Allelic variation in class I HLA determines CD8(+) T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2 |
| title_sort | allelic variation in class i hla determines cd8(+) t cell repertoire shape and cross-reactive memory responses to sars-cov-2 |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017864/ https://www.ncbi.nlm.nih.gov/pubmed/34793243 http://dx.doi.org/10.1126/sciimmunol.abk3070 |
| work_keys_str_mv | AT francisjoshuam allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT leistritzedwardsdel allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT dunnaugustine allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT tarrchristina allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lehmanjesse allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT dempseyconor allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hamelandrew allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT rayonvioleta allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT liugang allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT wangyuntong allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT willemarcos allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT durkinmelissa allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hadleykane allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sheenaaswathy allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT roscoebenjamin allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ngmark allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT rockwellgraham allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT mantomargaret allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT giengerelizabeth allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT nickersonjoshua allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT moarefiamir allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT noblemichael allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT maliathomas allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT bardwellphilipd allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT gordonwilliam allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT swainjoanna allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT skobernemojca allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sauerkarsten allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT harristim allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT goldrathanandaw allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT shalekalexk allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT coyleanthonyj allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT benoistchristophe allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT pregibondanielc allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT jilgnikolaus allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lijonathan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT rosenthalalex allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT wongcolline allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT daleygeorge allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT golandavid allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hellerhoward allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sharpearlene allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT abaynehbetelihema allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT allenpatrick allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT antillediane allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT armstrongkatrina allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT boycesiobhan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT braleyjoan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT branchkaren allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT broderickkatherine allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT carneyjulia allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT chanandrew allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT davidsonsusan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT douganmichael allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT drewdavid allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ellimanashley allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT flahertykeith allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT flanneryjeanne allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT fordepamela allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT gettingselise allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT griffinamanda allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT grimmelsheila allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT grinkekathleen allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hallkathryn allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT healymeg allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT henaultdeborah allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hollandgrace allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT kayitesichantal allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lavallevlasta allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT luyuting allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT luthernsarah allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT schneiderjordanmarchewka allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT martinobrittani allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT mcnamararoseann allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT nambuchristian allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT nelsonsusan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT noonemarjorie allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ommerbornchristine allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT pachecoloischris allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT phannicole allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT portofalishaa allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ryanedward allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT selleckkathleen allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT slaughenhauptsue allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sheppardkimberlysmith allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT suschanaelizabeth allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT wilsonvivine allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT carringtonmary allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT martinmaureen allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT yukiyuko allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT altergalit allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT balazsalejandro allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT balsjulia allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT barbashmax allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT bartschyannic allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT boucaujulie allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT carringtonmary allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT chevalierjosh allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT chowdhuryfatema allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT demersedward allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT einkaufkevin allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT fallonjon allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT fedirkoliz allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT finnkelsey allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT garciabroncanopilar allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ghebremichaelmusies allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hartanaciputra allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT jiangchenyang allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT judgekelly allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT kaplonekpaulina allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT karpellmarshall allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT laipeggy allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lamevanc allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lefterikristina allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lianxiaodong allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lichterfeldmathias allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lingwooddaniel allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT liuhang allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT liujinqing allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT lynatasha allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT hillzacharymanickas allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT michellashlin allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT millstromilan allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT mirandanoah allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ocallaghanclaire allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT osbornmatthew allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT pillaishiv allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT rassadkinayelizaveta allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT reissisalexandra allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT ruzickafrancis allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT seigerkyra allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sessalibera allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sharrchristianne allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT shinsally allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT singhnishant allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sunweiwei allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT sunxiaoming allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT tichelihannah allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT trochapiechockaalicja allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT walkerbruce allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT worralldaniel allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT yuxug allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 AT zhualex allelicvariationinclassihladeterminescd8tcellrepertoireshapeandcrossreactivememoryresponsestosarscov2 |