Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

Many pathogenic missense mutations are found in protein positions that are neither well-conserved nor fall in any known functional domains. Consequently, we lack any mechanistic underpinning of dysfunction caused by such mutations. We explored the disruption of allosteric dynamic coupling between th...

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Detalles Bibliográficos
Autores principales: Ose, Nicholas J., Butler, Brandon M., Kumar, Avishek, Kazan, I. Can, Sanderford, Maxwell, Kumar, Sudhir, Ozkan, S. Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017885/
https://www.ncbi.nlm.nih.gov/pubmed/35389981
http://dx.doi.org/10.1371/journal.pcbi.1010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017885/
https://www.ncbi.nlm.nih.gov/pubmed/35389981
http://dx.doi.org/10.1371/journal.pcbi.1010006

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